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Showing 2 results for Saghaeian jazi
Docetaxel Toxicity Optimization in Esophageal Squamous Cell Carcinoma Cell Line YM-1: A Study of Cell Cycle and Doubling Time Effect
Boshra Haghi, Marie Saghaeian Jazi, Mahdi Zarie, Ayyoob Khosravi, Mahboubeh Tajaldini, Jahanbakhsh Asadi,
Volume 15, Issue 2 (Mar-Apr 2021)
Abstract
Background and objectives: Docetaxel is a chemotherapeutic agent commonly used for treatment of many cancers, including esophageal squamous cell carcinoma. Docetaxel induces G2/M phase cell cycle arrest and ultimately cell death. In this study, we aimed to assess the effects of docetaxel on YM1 cells considering exposure time and dose.
Methods: After calculating the doubling time of YM1 cells, the anti-proliferative effect of different concentrations of docetaxel () [A1]  after 24, 48 and 72 hours was assessed by the standard colorimetric assay. In addition, the effect of docetaxel on cell cycle was evaluated by flow cytometry.
Results: The results showed that docetaxel toxicity was not significant until 24 hours at the tested concentrations (P>0.05). In addition, the effect of docetaxel on the cells was time-dependent at all tested concentrations. Overall, the duration of exposure to docetaxel had more significant role in docetaxel toxicity in YM1 cells compared to concentration.
Conclusion: Our findings suggest that the cytotoxicity of docetaxel on YM1 cells is time-dependent.
 [A1]Please write the concentrations

Association between lipid metabolism markers and gastric cancer stage and grade: A Focus on ApoB
Amir Asghary, Marie Saghaeian Jazi , Seyed Mostafa Mir , Abbas Doulani , Hamid Reza Joshaghani,
Volume 20, Issue 2 (6-2026)
Abstract
Background: Gastric cancer (GC), particularly adenocarcinoma, remains a major global health burden with high mortality, largely because of late-stage diagnosis and the limited availability of reliable biomarkers for disease monitoring. Lipid metabolism plays a crucial role in tumor biology, and serum lipid-related markers, including apolipoproteins, have been proposed as potential non-invasive indicators of tumor progression. This study aimed to evaluate the association between serum lipid profiles and tumor stage and histological grade in patients with gastric adenocarcinoma.
Methods: Fifty patients diagnosed with gastric adenocarcinoma were enrolled. Serum levels of total cholesterol, triglycerides, HDL-C, LDL-C, ApoA1, and ApoB were measured. Patients were categorized into early (Stages I-II) and advanced (Stages III-IV) tumor stages, as well as into moderately differentiated versus poorly differentiated grades. The Shapiro-Wilk test was used to assess data normality. Parametric and non-parametric tests were applied accordingly. A p-value < 0.05 was considered statistically significant.
Results: ApoB was the only parameter showing a significant association with tumor stage. Patients with advanced-stage GC had significantly lower mean ApoB levels than those in early stages (52.4 ± 2.6 vs. 63.4 ± 5.2 mg/dL, p = 0.042). No statistically significant differences were observed in ApoA1, HDL-C, total cholesterol, triglycerides, LDL-C, or VLDL with respect to either tumor stage or histological grade.
Conclusion: ApoB levels appear to decline with advancing tumor stage in gastric adenocarcinoma, suggesting a potential role as a marker for evaluating disease burden. Although no association was found with tumor grade, further validation in larger prospective studies incorporating metabolic and inflammatory covariates is warranted.

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