Amirhossein Parmah, Ebrahim Kouhsari, Taraneh Esmaeili, Majid Dastorani, Saeid Amirkhanlou,
Volume 20, Issue 4 (9-2026)
Abstract
Background: COVID-19 significantly affected global health, with research linking dysnatremia to increased ICU admission and mechanical ventilation in patients. Sodium abnormalities also complicate recovery, treatment, and hospitalization duration. This study further investigates the relationship between sodium abnormalities and hospitalization length in COVID-19 patients. Objectives: To evaluate the association between sodium abnormalities (hyponatremia and hypernatremia) and length of hospitalization in patients with COVID-19. Methods: A retrospective study was conducted on patients with PCR-confirmed COVID-19 between 2019 and 2021. Data collection involved reviewing medical records, laboratory findings, and conducting telephone interviews with patients. Results: The study comprised 129 participants, with a male-to-female ratio of 54.3% to 45.7%. Hyponatremia was present in 44.2% (n=57) of patients. Statistical analysis using the Spearman correlation coefficient and Kruskal-Wallis test revealed no significant relationship between serum sodium levels and length of hospitalization (P=0.789 and P=0.854, respectively). Conclusion: Despite previous reports of an association between sodium disorders and morbidity/mortality in COVID-19 patients, this study did not find a significant relationship between the two variables. Further research is warranted to explore the potential impact of sodium abnormalities on COVID-19 patient outcomes.
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