Background: Obesity and prediabetes are associated with chronic low-grade inflammation, and macrophage-related markers such as IL-10, Dectin-1, and IL-1Ra play a key role in modulating inflammatory responses. The purpose of this study was to investigate the effect of a period of high-intensity functional training (HIFT) on IL-10, Dectin-1, and IL-1Ra in prediabetic obese women to assess the impact of this exercise modality on M2 macrophage markers.
Methods: Thirty eligible female volunteers aged 35-40 years were selected and homogeneously divided into two groups: 1) control (n=15) and 2) training (n=15). The training group underwent a 16-week HIFT program based on CrossFit protocols, incorporating squats, deadlifts, barbell/dumbbell exercises, kettlebell swings, and aerobic/weight-bearing movements in a Workout of the Day format (60 min/session). The control group maintained their daily routines without structured exercise. Serum levels of Dectin-1, IL-10, and IL-1Ra were measured via ELISA. Descriptive statistics (Mean, standard deviation) were used for data analysis.
Results: After 16 weeks, HIFT significantly reduced Dectin-1 (P = 0.048) and increased IL-10 (P < 0.0001) and IL-1Ra (P < 0.0001) levels in prediabetic obese women.
Conclusion: These findings suggest that 16 weeks of HIFT may enhance anti-inflammatory markers (IL-10, IL-1Ra) and modulate Dectin-1, potentially mitigating obesity-related inflammatory complications in prediabetic women.
