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Showing 5 results for Inflammation
Curcumin (Extracted from Tumeric) and its Therapeutic Effects
Arezou Khosrojerdi, Kazem Mashayekhi, Hadi Zare Marzouni,
Volume 4, Issue 2 (10-2016)
Abstract

Background and Objectives:  The application of herbal medicine has been rising in recent years. Therefore, it is logical to revise and revive these traditional drugs while identifying their mechanisms of action can result in developing new treatments for many diseases. Curcumin is the most important component of Turmeric with numerous therapeutic properties. We aimed to review the anti-inflammatory and anti-microbial properties of Curcumin and introduce it as a therapeutic molecule in the present article.

Methods: In this review, 121 articles were selected from authenticated electronic resources and scientific library databases such as Pubmed, Medline, Sciencedirect, WOS, DOAJ, SID, Iranmedex, Magiran and Google Scholar search engine in which Curcumin (Turmeric) had been evaluated as a therapeutic molecule from differeny aspects.

Results: Our findings from the literature revealed that immune responses against infectious and inflammatory factors could be fascilitated by Curcumin. However, the low solubility in water and minimal bioavailability which may lead to poor absorbance from gastrointestinal tract, quick metabolization and elimination from blood circulation are the most important problems during oral consumption.

Conclusion: According to the results of the present review article, Curcumin possesses efficient anti-inflammatory, anti-microbial, anti-viral and anti-parasitic properties. However, the low bioavailability of this substance has limited its treatment properties. Nowadays, several mechanisms have been proposed to increase the bioavailability which can improve its absorption.


The Health-Related Biological Effects of Date Palm Pollen (DPP) along with Physical Activity: A Narrative Mini-Review
Soheil Abdollahi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Saleh Rahmati-Ahmadabad,
Volume 10, Issue 4 (12-2022)
Abstract
Date Palm Pollen (DDP), which is found in the male date tree, actually fertilizes the female date tree, which is necessary for the growth of date fruit. It is consisting of sugarcane, protein, calcium, vitamins (B, C and E) and minerals. It has long been used in traditional medicine as a medicinal plant with fertility effects and increased libido. The information obtained from the studies shows that this pollen, due to its antioxidant and gonadotropin-stimulating compounds, can increase fertility and sexual potency in both women and men with two main mechanisms. The first mechanism is this effect on the stimulation of gonadotrophic hormones and the second is a reduction of oxidative stress in the testicular tissue and consequently a protective effect on the testicular tissue. Due to the presence of antioxidant compounds, the consumption of this pollen also applies its health-enhancing effects to other tissues such as the liver, intestines, and heart. As same as DDP, regular Physical Activity (PA) stimulates gonadotrophic hormones and also beneficially affects antioxidant status and redox balance. In recent years, researchers have paid attention to this pollen as an important factor to strengthen the health-enhancing effects of PA, and researchers have investigated the simultaneous effect of this pollen and PA. Despite the few studies done, it seems that this pollen can enhance the antioxidant and anti-inflammatory effects of regular PAs. Nevertheless, it seems necessary to further studies in this area.

Comparison of twelve weeks periodized circuit resistance training and traditional resistance training on calprotectin levels in obese men
Fatemeh Mirzaei Ashrafi, Seyed Mohsen Avandi, Ali Khaleghian,
Volume 11, Issue 1 (7-2023)
Abstract
Fatemeh Mirzaei Ashrafi http://jorjanijournal.goums.ac.ir/files/0allsites/images/orcid.png, Seyed Mohsen Avandi  http://jorjanijournal.goums.ac.ir/files/0allsites/images/orcid.png , Ali Khaleghian http://jorjanijournal.goums.ac.ir/files/0allsites/images/orcid.png

Background: Obesity has become a significant health concern in recent decades, characterized by increased body fat. This study aimed to compare the effects of circuit and traditional resistance training on serum calprotectin levels in obese men.
Methods: A pre-test-post-test design was used with thirty-three sedentary young obese men (age 21.33±2.49 years, weight 92.23±14.39 kg and BMI 30.71±4.63 kg/m²) who were randomly divided into two groups: experimental and control. The experimental group underwent a 12-week periodized resistance training program consisting of three sessions per week, gradually increasing in intensity from 50% to 80% of their one-repetition maximum (1RM) using a wave pattern. Resting serum calprotectin levels were measured before and after the intervention. Data were analyzed using analysis of variance (ANOVA) and paired sample t-tests, with statistical significance at p < 0.05.
Results: Both periodized circuit and traditional resistance training resulted in increased plasma levels of calprotectin compared to the control group (p = 0.001). Additionally, the periodized circuit resistance training group demonstrated a greater increase in plasma levels of calprotectin than the traditional resistance training and control groups (p = 0.01).
Conclusion: These findings suggest that twelve-week periodized circuit and traditional resistance training programs can effectively increase calprotectin levels in obese men.

Investigation of the effect of six weeks of swimming on the caspase-1, TGF-β1, and IFN- γ protein content in the hippocampal tissue of rats with multiple sclerosis
Ali Esmaeili , Abdolhamid Habibi , Mohammad Rami , Mehrzad Shabani ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: Performing exercise training with various protocols, especially aquatic exercises, can be effective against the harmful effects of Multiple Sclerosis. Therefore, the present study aimed to investigate the effect of six weeks of swimming training on the Caspase-1, TGF-β1, and IFN-γ protein content in the hippocampal tissue of rats with Multiple Sclerosis.
Methods: Twenty-one Wistar rats were divided into three equal groups: (1) Healthy control, (2) Multiple Sclerosis control, and (3) Multiple Sclerosis swimming. After two weeks of adaptation to the laboratory environment, the Multiple Sclerosis groups were induced by adding cuprizone to their diet. Six weeks of swimming training were then performed. Forty-eight hours after the last session, hippocampal tissue was isolated to examine Caspase-1, TGF-β1, and IFN-γ protein content. To analyze the data, one-way analysis of variance was used with a significance level of 0.05.
Results: Findings showed that the induction of Multiple Sclerosis in rats caused a significant increase in TGF-β1 and Caspase-1 protein content (P-Value=0.001) and a significant decrease in IFN-γ (P-Value =0.001). After six weeks of swimming, there was a significant decrease in Caspase-1 (P-Value =0.001) and a significant increase in IFN-γ (P-Value =0.001) protein content; however, there was no significant decrease in TGF-β1 protein content (P-Value =0.1).
Conclusion: Based on the findings of this study, it can be concluded that swimming, as a non-pharmacological intervention, has a protective effect on nerves by reducing factors related to inflammation and cell death, which may have beneficial effects on memory information processing in Multiple Sclerosis disease.
 

The effect of six weeks HIIT exercise on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats
Sara Ghasdi , Mohammad Rami , Abdolhamid Habibi ,
Volume 13, Issue 1 (9-2025)
Abstract
Background: Research has shown that high-intensity interval training (HIIT) is a convenient and time-efficient approach that promotes oxidative capacity. Therefore, this study aimed to investigate the effect of HIIT on the gene expression of some inflammatory and anti-inflammatory markers of hippocampal tissue in aged male Wistar rats.
Methods: In this experimental study, 21 male Wistar rats were divided into three equal groups: 1- control (C), 2- elderly control (EC), and 3- elderly training (ET). After two weeks of adaptation to the laboratory environment, six weeks of HIIT were performed for the training group. Forty-eight hours after the last training session, hippocampal tissue was isolated to examine the mean levels of interleukin-10 (IL-10), IL-6, and IL-1β gene expression. One-way analysis of variance and Tukey's post-hoc test with a significance level of 0.05 were used to analyze the data.
Results: There was a significant increase in the expression of IL-6 and IL-1β, while a significant decrease in IL-10 expression (p=0.001) in the C group compared to the EC. After six weeks of HIIT, expression of IL-6 (p=0.001) and IL-1β (p=0.001) significantly decreased, whereas IL-10 expression significantly increased (p=0.001) in the ET group compared to the EC group.
Conclusion: It seems that HIIT activity has beneficial effects on preventing the process of neural degeneration. Moreover, it is promising as a non-pharmacological strategy for controlling complications resulting from the aging process due to its anti-inflammatory properties.

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